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Cidofovir Molluscum Treatment

cidofovir-molluscumCidofovir is a potent antiviral medication that is typically used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.  Its mechanism of action involves the inhibition of DNA polymerase activity.  What this means is that it interferes with the production of new cells and other necessary elements for the survival of many viruses.  In addition to its benefits for CMV, cidofovir demonstrated efficacy agains poxviruses, the family to which molluscum contagiosum belongs.

Cidofovir is typically an injectible medication but its active drug can by formulated into a topical gel.  Case studies of the use of this topical preparation have shown to be extremely successful at treating molluscum, primarily being used in difficult cases involving immunosuppressed patients (mostly with AIDS)1-2

The cost of cidofovir is extremely high and this is typically used as a last resort in cases that are unresponsive to more conventional therapy.

1Antiviral Res. 2002 Jul;55(1):1-13.

2Rev Med Virol. 2004 Sep-Oct;14(5):289-300.

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